## Abstract Berberine has been shown to have anti‐carcinogenic effects. Since p53 is the most commonly mutated tumor suppressor gene, and a lack of functional p53 is associated with an increased risk of cancer development, we examined the effects of berberine on p53‐positive and p53‐deficient non‐s
✦ LIBER ✦
PIM-1 gene RNA interference induces growth inhibition and apoptosis of prostate cancer cells and suppresses tumor progression in vivo
✍ Scribed by Tong Zhang; Xiaoguang Zhang; Kejia Ding; Kuo Yang; Zhihong Zhang; Yong Xu
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 510 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0022-4790
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## BACKGROUND. The mechanism behind castration-induced apoptosis in prostate cells is unknown, but data from other species suggest that transforming growth factor 1 (TGF-1) may be involved. METHODS. By using quantitative RT-PCR and immunohistochemistry, expression of TGF-1 and its receptors typ