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PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus

โœ Scribed by Ahn, Jee-Yin; Rong, Rong; Liu, Xuesong; Ye, Keqiang


Book ID
110030785
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
546 KB
Volume
23
Category
Article
ISSN
0261-4189

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The antiapoptotic effect of guanosine is
โœ Patrizia Di Iorio; Patrizia Ballerini; Ugo Traversa; Ferdinando Nicoletti; Iolan ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 309 KB ๐Ÿ‘ 1 views

## Abstract Guanosine has many trophic effects in the CNS, including the stimulation of neurotrophic factor synthesis and release by astrocytes, which protect neurons against excitotoxic death. Therefore, we questioned whether guanosine protected astrocytes against apoptosis induced by staurosporin