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Pigs transgenic for human thrombomodulin have elevated production of activated protein C

✍ Scribed by Björn Petersen; Wolf Ramackers; Andreas Tiede; Andrea Lucas-Hahn; Doris Herrmann; Brigitte Barg-Kues; Wolfgang Schuettler; Lars Friedrich; Reinhard Schwinzer; Michael Winkler; Heiner Niemann


Book ID
110905054
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
480 KB
Volume
16
Category
Article
ISSN
0908-665X

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We investigated the role of anticoagulant in the ischemia/reperfusion injury of the liver, using activated protein C (APC), active human urinary thrombomodulin (UTM), and factor Xa blocked at the active site (DEGR-Xa). Liver ischemia was induced in male Wistar rats by occlusion of the portal vein wi