## Abstract In this study, we investigated whether overexpression of pigment epitheliumβderived factor (PEDF) by gene transfer can inhibit neovascularization by testing its effect in three different models of ocular neovascularization. Intravitreous injection of an adenoviral vector encoding PEDF r
Pigment epithelium-derived factor protects retinal pigment epithelium from oxidant-mediated barrier dysfunction
β Scribed by Tsung-Chuan Ho; Yuh-Cheng Yang; Huey-Chuan Cheng; Ai-Ching Wu; Show-Li Chen; Yeou-Ping Tsao
- Book ID
- 116292357
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 465 KB
- Volume
- 342
- Category
- Article
- ISSN
- 0006-291X
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π SIMILAR VOLUMES
Pigment epithelium-derived factor (PEDF) is a neurotrophic protein synthesized and secreted by retinal pigment epithelial (RPE) cells in early embryogenesis and has been shown to be present in the extracellular matrix between the RPE cells and the neural retina. It induces neuronal differentiation a
## Abstract In conditions in which the retinal pigment epithelium (RPE) is dystrophic, carries a genetic mutation, or is removed physically, MΓΌller cells undergo degenerative changes that contribute to the retinal pathology. We previously demonstrated that pigment epitheliumβderived factor (PEDF),