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Pictet–Spengler synthesis of tetrahydro-β-carbolines using vinylsulfonylmethyl resin

✍ Scribed by Richard V. Connors; Alex J. Zhang; Stephen J. Shuttleworth

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
158 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

A novel, solid phase Pictet-Spengler synthesis has been developed using vinylsulfonylmethyl resin. A library of 800 structurally diverse tetrahydro-b-carbolines was prepared in a four-step sequence starting from tryptamines. The final resin cleavage step enabled the introduction of a basic tertiary amine in the six-membered heterocyclic ring.

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