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Pictet-Spengler reactions of epinephrine with formaldehyde and acetaldehyde

✍ Scribed by Bates, Hans Aaron


Book ID
115456764
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
727 KB
Volume
46
Category
Article
ISSN
0022-3263

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Synthesis of optically pure pyrroloquino
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Diastereomers of substituted 2,3,4,9-tetrahydro-1H-b-carbolines were synthesized via asymmetric Pictet-Spengler reaction of the chiral tryptamine derived from R-1-naphthalen-1-yl-ethylamine with 67% of d.e. The S,R-b-carboline can be converted to the R,R form by treating with TFA. Optically pure pyr