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Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and β-arrestin1

✍ Scribed by Girnita, L; Larsson, O; Vasilcanu, R; Vasilcanu, D; Rosengren, L; Natalishvili, N; Sehat, B; Yin, S; Girnita, A; Axelson, M


Book ID
110072784
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
465 KB
Volume
27
Category
Article
ISSN
0950-9232

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✍ Su Wol Chung; Min-Young Kwon; Young-Ho Kang; Hun-Taeg Chung; Seon-Jin Lee; Hong 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 785 KB

## Abstract Heme oxygenase (HO)‐1 is a cytoprotective molecule that is induced during the response to injury. An increase in HO‐1 is an acute indicator of inflammation, and early induction of HO‐1 has been suggested to correlate with severity of injury. While a great deal is known about the inducti