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Picking a winner: new mechanistic insights into the design of effective siRNAs

โœ Scribed by Delquin Gong; James E. Ferrell Jr


Book ID
113931795
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
109 KB
Volume
22
Category
Article
ISSN
0167-7799

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## Abstract The membrane mucin Muc4 is aberrantly expressed in numerous epithelial carcinomas and is currently used as a cancer diagnostic and prognostic tool. Muc4 can also potentiate signal transduction by modulating differential ErbB2 phosphorylation in the absence and in the presence of the Erb