𝔖 Bobbio Scriptorium
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Picenadol, a mixed opioid agonist/antagonist without κ opioid agonist activity in the rat urination test

✍ Scribed by J. David Leander; Dennis M. Zimmerman

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
442 KB
Volume
3
Category
Article
ISSN
0272-4391

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## Opioid receptor agonists (e.g.,488) increase the locomotor activity of preweanling rats, while the same drugs depress the locomotor activity of adults. Curiously, direct stimulation of dopamine (DA) D 2 -like receptors fully attenuates the U-50,488-induced locomotor activity of preweanling rats