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PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

✍ Scribed by Barber, Domingo F; Bartolomé, Almira; Hernandez, Carmen; Flores, Juana M; Redondo, Clara; Fernandez-Arias, Cristina; Camps, Montserrat; Rückle, Thomas; Schwarz, Matthias K; Rodríguez, Santiago; Martinez-A, Carlos; Balomenos, Dimitrios; Rommel, Christian; Carrera, Ana C


Book ID
109932601
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
337 KB
Volume
11
Category
Article
ISSN
1078-8956

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✍ Carla Zoja; Federica Casiraghi; Sara Conti; Daniela Corna; Daniela Rottoli; Regi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 262 KB

## Abstract ## Objective To examine whether the cyclin‐dependent kinase (CDK) inhibitor seliciclib ameliorates autoimmune nephritis in (NZB × NZW)F~1~ mice. ## Methods In experiment 1, NZB × NZW mice received seliciclib (100 mg/kg or 200 mg/kg) or vehicle by gavage, beginning at age 2 months and