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PI3K/AKT signaling pathway and cancer: an updated review

✍ Scribed by Martini, Miriam; De Santis, Maria Chiara; Braccini, Laura; Gulluni, Federico; Hirsch, Emilio


Book ID
124066120
Publisher
Informa plc
Year
2014
Tongue
English
Weight
616 KB
Volume
46
Category
Article
ISSN
0785-3890

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## Abstract Activated phosphoinositide 3‐kinase (PI3K) and its downstream target Akt/PKB are important signaling molecules and key survival factors involved in the control of cell proliferation, apoptosis and oncogenesis. We investigated the role of the PI3K‐Akt signaling pathway in the invasion of