PI3K/Akt activity has variable cell-specific effects on expression of HIF target genes, CA9 and VEGF, in human cancer cell lines

Effects of pharmacologic antagonists of

Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-κB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines

✍ Caren C. Bancroft; Zhong Chen; Jason Yeh; John B. Sunwoo; Ning T. Yeh; Sadhana J 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 296 KB 👁 2 views

## Abstract We previously reported that expression of angiogenesis factors interleukin‐8 (IL‐8) and vascular endothelial growth factor (VEGF) is promoted by coactivation of transcription factors nuclear factor‐kappaB (NF‐κB) and activator protein‐1 (AP‐1) by interleukin‐1α in human head and neck sq