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PI3K and Notch signal pathways coordinately regulate the activation and proliferation of T lymphocytes in asthma

✍ Scribed by Zhang, Weixi; Nie, Ying; Chong, Lei; Cai, Xiaohong; Zhang, Hui; Lin, Beibei; Liang, Yafeng; Li, Changchong

Book ID
123235802
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
599 KB
Volume
92
Category
Article
ISSN
0024-3205

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## Abstract Notch signalling plays an important role in hematopoiesis and in the pathogenesis of T‐ALL. Notch is known to interact with Ras and PTEN/PI3K (phosphoinositide‐3 kinase)/Akt pathways. We investigated the interaction of Notch with these pathways and the possible reciprocal regulation of