## Abstract Giant cell tumor (GCT) of bone is a unique bone lesion that is characterized by an excessive number of multinucleated osteoclasts. GCT consists of neoplastic stromal cells, multinucleated osteoclasts and their precursors, thus serving as a naturally occurring human disease model for the
PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1)
โ Scribed by Bjoern F. Kraemer; Oliver Borst; Eva-Maria Gehring; Tanja Schoenberger; Benjamin Urban; Elena Ninci; Peter Seizer; Christine Schmidt; Boris Bigalke; Miriam Koch; Ivo Martinovic; Karin Daub; Tobias Merz; Laura Schwanitz; Konstantinos Stellos; Fabienne Fiesel; Martin Schaller; Florian Lang; Meinrad Gawaz; Stephan Lindemann
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 796 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0946-2716
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Osteoporosis and its complications cause morbidity and mortality in the aging population, and result from increased bone resorption by osteoclasts in parallel with decreased bone formation by osteoblasts. A widely accepted strategy for improving bone health is targeting osteoprogenitor
Recently we found that an intracellular event related to phosphatidylinositol 4,5bisphosphate (PIP2) is crucial for platelet-derived growth factor (PDGF)-induced mitogenesis in fibroblastic cells (Matuoka, K., et al.: Science 239:640-643, 1988). In the present study we examined the mitogenic effects
The experiments presented here were designed to examine the contribution of the extracellular signal-regulated mitogen-activated protein kinases (ERKs) to the tyrosine phosphorylation of the focal adhesion proteins p125 Fak , p130 Cas , and paxillin induced by G protein-coupled receptors (GPCRs) and