✦ LIBER ✦

PI 3-kinase: a pivotal pathway in T-cell activation?

✍ Scribed by Stephen G. Ward; Carl H. June; Daniel Olive

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 790 KB
Volume: 17
Category: Article
ISSN: 0167-5699
DOI: 10.1016/0167-5699(96)80618-9

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

The role of the PI3K-AKT kinase pathway

The role of the PI3K-AKT kinase pathway in T-cell development beyond the β checkpoint

✍ Ling Xue; Leslie Chiang; Chulho Kang; Astar Winoto 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 340 KB

## Abstract The PI3K‐AKT pathway can mediate diverse biological responses and is crucial for optimal immune responses and lymphocyte development. Deletion of PI3K subunits or AKT leads to blockage of T‐cell development at the TCR‐β checkpoint. Studies with over‐expression of constitutively activate

Pathogenic T cells in murine lupus exhib

Pathogenic T cells in murine lupus exhibit spontaneous signaling activity through phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways

✍ Florin Niculescu; Phuong Nguyen; Teodora Niculescu; Horea Rus; Violeta Rus; Char 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB 👁 2 views

Activation of surfactant protein-B trans

Activation of surfactant protein-B transcription: Signaling through the SP-A receptor utilizing the PI3 kinase pathway

✍ David S. Strayer; Laxminarayana Korutla 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 239 KB 👁 2 views

Inhibitors of the PI3-kinase/Akt pathway

Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells

✍ Therese H Hemström; Margareta Sandström; Boris Zhivotovsky 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 696 KB

## Abstract Non‐small cell lung cancer cells (NSCLC) are more resistant to anticancer treatment as compared with other types of cancer cells. Recently (Hemström __et al__., Exp Cell Res 2005;305:200–13) we showed that apoptosis of U1810 NSCLC cells induced by the staurosporine analog PKC 412 correl

Purinergic activation of a tyrosine kina

Purinergic activation of a tyrosine kinase-dependent pathway in cardiac cells

✍ Michel Pucéat 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 163 KB 👁 1 views

This overview focuses on the role of cytosoluble tyrosine kinases in the purinergic regulation of cardiac function. Cardiac cells express many cytosolic tyrosine kinases, including pp60 c-src , p59 c-fyn , Csk, FAK, and Tec. Purinergic stimulation of cardiomyocytes increases the activity of pp60 c-s

Protein kinase C activation by anthracyc

Protein kinase C activation by anthracyclines in swiss 3T3 cells

✍ Cinzia Lanzi; Romolo Achille Gambetta; Paola Perego; Patrizia Banfi; Aimarita Fr 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 851 KB

The effects of the anti-cancer anthracyclines doxorubicin and daunorubicin on the activity of protein kinase C (PKC) were examined in intact Swiss 3T3 cells. The 2 drugs stimulated the phosphorylation of an 80K phosphoprotein found to be identical to that generated in response to the PKC activator 1