Phytoestrogen kaempferol (3,4′,5,7-tetrahydroxyflavone) protects PC12 and T47D cells from β-amyloid–induced toxicity
✍ Scribed by Adrian Roth; Willy Schaffner; Cornelia Hertel
- Book ID
- 101244861
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 121 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0360-4012
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✦ Synopsis
In clinical studies, it has been shown that estrogen replacement therapy in menopause is strongly correlated with a reduced risk of the development of Alzheimer's disease (AD). In in vitro experiments, it was demonstrated that estradiol protects cells against the toxic effects of -amyloid, the major component of plaques in brains of AD patients. Therefore, estrogens have become interesting candidates for a possible treatment of neurodegeneration. In plants, a class of compounds has been identified that bind to human estrogen receptor, so-called phytoestrogens, which are part of our daily diet. Here, we compared the effects of ␣and -estradiol with plant-derived kaempferol on -amyloid peptide-induced toxicity in PC12 neuroblastoma and T47D human breast cancer cells. The present results demonstrate a protective effect of kaempferol comparable to that observed with estradiol. The effects of the weak estrogen receptor agonists ␣-estradiol and kaempferol were found to be similar to the effects of the strong estrogen receptor agonist -estradiol, suggesting a mode of action independent from the nuclear estrogen receptor.