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Phytochemicals as a potential source for TNF-α inhibitors

✍ Scribed by Iqbal, Muzamal; Verpoorte, Robert; Korthout, Henrie A. A. J.; Mustafa, Natali Rianika

Book ID
118019894
Publisher
Springer
Year
2012
Tongue
English
Weight
810 KB
Volume
12
Category
Article
ISSN
1568-7767

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Our research on hydantoin based TNF-α converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency (K(i)) as well as excellent activity in human whole blood. These studies led to the discovery of highly potent TACE inhibitors with good DMPK pr