Production of the enzyme dihydrofolate r
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Poonam Nigam; Roger Marchant
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Article
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2007
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Wiley (John Wiley & Sons)
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English
β 449 KB
## Abstract Six bacterial cultures isolated from soil were capable of growing in the presence of methotrexate (MTX). Two strains, PFRβ1 and 3, developed resistance to 500 ΞΌg cm^β3^ MTX in the medium and produced elevated levels of the enzyme dihydrofolate reductase (EC 1.5.1.3): 2580 and 2702 U dm^