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Physostigmine analogs anticholinesterases: effects of the lengthening of the N-carbamic chain of the inhibition kinetics

✍ Scribed by Maurizio Marta; Franco Gatta; Massimo Pomponi

Book ID
113268832
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
300 KB
Volume
1120
Category
Article
ISSN
0167-4838

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Inhibition of acetylcholinesterase by ph
Inhibition of acetylcholinesterase by physostigmine analogs: Conformational mobility of cysteine loop due to the steric effect of the alkyl chain
✍ Enrico Gavuzzo; Massimo Pomponi πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 668 KB

## Abstract The effect of a series of physostigmine analogs on acetylcholinesterase activity was investigated. The second‐order rate constant __k__~on~ of the enzyme–inhibitor complex correlates with the conformational positioning of aromatic residues, especially Trp84, in the transition state comp