Physiologically guided angioplasty in support to a provisional stenting strategy: Immediate and six-month outcome
✍ Scribed by Patrick Dupouy; Gabriel Pelle; Philippe Garot; Morton J. Kern; G. Kane; Javier Woscoboinick; Eduardo Aptecar; Abdel Belarbi; Jean Marie Pernés; Jean Luc Dubois Randè; Emmanuel Teiger
- Book ID
- 101314589
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 94 KB
- Volume
- 49
- Category
- Article
- ISSN
- 1522-1946
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✦ Synopsis
The results of an observational multicenter angioplasty study suggested that stenting decisions may be facilitated by physiologic data. The purpose of this study was to evaluate the early and long-term clinical and angiographic outcome of prospective physiologically guided provisional stenting. Coronary angioplasty using a Doppler-tipped angioplasty guidewire was performed in 68 patients. The provisional stent strategy dictated that balloon angioplasty was to be continued until a coronary flow reserve was ≥ 2.2 with a residual diameter stenosis by quantitative coronary angiography < 35%. Repeat coronary angiography was obtained at 6 months. Based on the study criteria, 32/68 patients (47%) received a stent. Compared to the stent group, the angioplasty alone group had higher postprocedural stenosis (23% ؎ 13% vs. 13% ؎ 10%; P < 0.05) and lower coronary vasodilatory reserve (2.3 ؎ 0.4 vs. 2.6 ؎ 0.7; P < 0.05). At follow-up (6.0 ؎ 1.5 months), the angiographic restenosis rate was 39% in the angioplasty group and 35% in the stent groups (P ؍ NS). Adverse cardiac events (unstable angina, target lesion revascularization, myocardial infarction, death) occurred in 19% and 18% (P ؍ NS) of the angioplasty and stent patients, respectively. A prospective application of a physiologically guided provisional stent strategy for coronary angioplasty indicated that stent implantation may be required in approximately 50% of patients, an approach that produces similar clinical and angiographic long-term outcomes for stenting and guided angioplasty. These data support a role of coronary physiology as an adjunct in conducting an angioplasty procedure without obligatory stenting.