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Physiologically based toxicokinetic modelling as a tool to assess target organ toxicity in route-to-route extrapolation—The case of coumarin

✍ Scribed by Hans Mielke; Klaus Abraham; Mario Götz; Bärbel Vieth; Alfonso Lampen; Andreas Luch; Ursula Gundert-Remy

Book ID
116923761
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
559 KB
Volume
202
Category
Article
ISSN
0378-4274

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A physiologic model to describe bupivacaine uptake by and elimination from brain and heart was developed. Preliminary validation of the model was accomplished by comparing concentration data predicted by the model with those determined in rabbits. The model was modified to examine similarities and d