Plasma kinetics and renal excretion of iodopyracet (3\*0g, adminstered i.v.) with and without concomitant administration of probenecid were studied in the beagle dog. Pharmacokinetic analysis revealed that tubular secretion is the predominant route of excretion, and that secretion is inhibited by pr
Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone
✍ Scribed by H. A. El-Masri; Russell S. Thomas; G. Rob Sabados; Jenny K. Phillips; Alexander A. Constan; Stephen A. Benjamin; Melvin E. Andersen; Harihara M. Mehendale; Raymond S. H. Yang
- Publisher
- Springer-Verlag
- Year
- 1996
- Tongue
- English
- Weight
- 288 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0340-5761
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Background: Rivaroxaban is an oral Factor Xa inhibitor. The primary objective of this communication was to quantitatively predict changes in rivaroxaban exposure when individuals with varying degrees of renal impairment are co-administered with another drug that is both a P-gp and a moderate CYP3A4
## Abstract The nonlinear pharmacokinetics of capecitabine, a triple prodrug of 5‐FU preferentially activated in tumour tissues, was investigated in human cancer xenograft models. A physiologically based pharmacokinetic (PBPK) model integrating the activation process of capecitabine to 5‐FU and 5‐F