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Physiologically based pharmacokinetic (PBPK) modeling: It is here to stay!

✍ Scribed by Amin Rostami-Hodjegan; Ikumi Tamai; K. Sandy Pang

Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
63 KB
Volume
33
Category
Article
ISSN
0142-2782

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✍ Joseph A. Grillo; Ping Zhao; Julie Bullock; Brian P. Booth; Min Lu; Kathy Robie- 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 535 KB

Background: Rivaroxaban is an oral Factor Xa inhibitor. The primary objective of this communication was to quantitatively predict changes in rivaroxaban exposure when individuals with varying degrees of renal impairment are co-administered with another drug that is both a P-gp and a moderate CYP3A4