Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 1: methotrexate
β Scribed by Ogungbenro, Kayode; Aarons, Leon
- Book ID
- 125364120
- Publisher
- Springer
- Year
- 2014
- Tongue
- English
- Weight
- 725 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1573-8744
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π SIMILAR VOLUMES
We studied the disposition phannacokinetics of methotrexate (MTX) given orally to 16 children with acute lyrnphoblastic leukemia (ALL) and its relation to the pharrnacokinetics of 6-mercaptopurine (6MP) in the same children. There was an eightfold variability in area-under-concentration tirnecurve (
A randomized study of methotrexate vs. 6-mercaptopurine and prednisone was carried out in 45 previously untreated patients with acute leukemia. Methotrexate was given orally in divided daily doses for 5-day courses a t intervals of ten to 14 days. Six-mercaptopurine and prednisone were given daily u