Physiologically based pharmacokinetic modeling of blood and tissue epoxide measurements for butadiene
β Scribed by Lisa M. Sweeney; Matthew W. Himmelstein; Paul M. Schlosser; Michele A. Medinsky
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 330 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0300-483X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The biosynthetically doubleβlabeled lipopolysaccharide (LPS), containing ^3^Hβlabeled on the fatty acylβchains and ^14^Cβlabeled on the glucosamine of __Salmonella enterica serotype typhimurium__, was isolated from bacteria grown in proteose peptoneβbeef extract (PPBE) medium in the pre
In this paper we present three physiologically based pharmacokinetic (PBPK) models for the systemic transport of trichloroethylene (TCE), with a focus on the adipose, or fat tissue. TCE is a widespread environmental contaminant, and has been shown to produce toxic effects in both animals and humans.
A key component of whole body physiologically based pharmacokinetic (WBPBPK) models is the tissue-to-plasma water partition coefficients (Kpu's). The predictability of Kpu values using mechanistically derived equations has been investigated for 7 very weak bases, 20 acids, 4 neutral drugs and 8 zwit