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Physiological roles of MKK4 and MKK7: Insights from animal models

✍ Scribed by Xin Wang; Auriane Destrument; Cathy Tournier

Book ID
113486024
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
415 KB
Volume
1773
Category
Article
ISSN
0167-4889

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## Abstract ## Objective The mitogen‐activated protein (MAP) kinase JNK is a key regulator of interleukin‐1 (IL‐1)–induced collagenase gene expression and joint destruction in arthritis. Two upstream kinases, MKK‐4 and MKK‐7, have been identified as potential activators of JNK. However, the role o