✦ LIBER ✦

Physiological perfusion model for cephalosporin antibiotics I: Model selection based on blood drug concentrations

✍ Scribed by D. S. Greene; R. Quintiliani; C. H. Nightingale

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 563 KB
Volume: 67
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600670217

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✦ Synopsis

Various cephalosporins with different degrees of protein binding were administered to human volunteers. Blood samples were collected as a function of time and were assayed for drug content by a microbiological assay. A pharmacokinetic analysis of the data was performed using a two-compartment model with and without protein binding in the central compartment and a perfusion model. Both the two-compartment model without protein binding and the physiological perfusion model adequately described the blood levels of all three cephalosporins.

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