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Physiological modulation of the GABA receptor by convulsant and anticonvulsant barbiturates in cultured rat hippocampal neurons

โœ Scribed by Katherine D. Holland; Daniel J. Canney; Steven M. Rothman; J.A. Ferrendelli; Douglas F. Covey

Book ID
115800768
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
326 KB
Volume
516
Category
Article
ISSN
0006-8993

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Chloride currents were activated by a low concentration of GABA (0.5 microM) in neonatal rat hippocampal neurons cultured for up to 14 days. Currents elicited by 0.5 microM GABA in neurons, voltage-clamped using the whole-cell technique with pipettes containing 149 mM Cl-, reversed close to 0 mV whe