✦ LIBER ✦

Physiological implications of adenosine receptor-mediated platelet aggregation

✍ Scribed by Hillary A. Johnston-Cox; Dan Yang; Katya Ravid

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 174 KB
Volume: 226
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.22379

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Adenosine is an important mediator of inhibition of platelet activation. This metabolite is released from various cells, as well as generated via activity of ecto‐enzymes on the cell surface. Binding of adenosine to A~2~ subtypes (A~2A~ or A~2B~), G‐protein coupled adenosine receptors, results in increased levels of intracellular cyclic adenosine monophosphate (cAMP), a strong inhibitor of platelet activation. The role and importance of adenosine and its receptors in platelet physiology are addressed in this review, including recently identified roles for the A~2B~ adenosine receptor as a modulator of platelet activation through its newly described role in the control of expression of adenosine diphosphate (ADP) receptors. J. Cell. Physiol. 226: 46–51, 2010. © 2010 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Molecular physiology of platelet ADP rec

Molecular physiology of platelet ADP receptors

✍ Satya P. Kunapuli 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 118 KB 👁 1 views

Extracellular nucleotides have been implicated in a number of physiologic functions. Nucleotides act on cell surface receptors known as P2 receptors of which several subtypes have been cloned. Both ATP and ADP are stored in platelets and are released upon platelet activation. During vascular injury,

Deaza analogues of adenosine as inhibito

Deaza analogues of adenosine as inhibitors of blood platelet aggregation

✍ Ippolito Antonini; Gloria Cristalli; Palmarisa Franchetti; Mario Grifantini; San 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB

Absence of platelet activating factor (P

Absence of platelet activating factor (PAF) mediated platelet aggregation: A new platelet defect

✍ Catherine J. Pelczar-Wissner; Elizabeth G. McDonald; Ira I. Sussman 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 201 KB 👁 2 views

The failure of normal human platelets to aggregate in response to platelet activating factor (PAF) has not been previously observed. We report here the first case of a patient whose platelets did not aggregate to PAF on multiple occasions.

Platelet 5-HT2A-receptor-mediated induct

Platelet 5-HT2A-receptor-mediated induction of aggregation is not altered in major depression

✍ Esther Gómez-Gil; Cristóbal Gastó; Maribel Díaz-Ricart; Marta Carretero; Manel S 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB 👁 1 views

## Background: Studies of the 5-ht(2a) receptor subtype in major depression have focused on the density of these receptors in neuronal cells and platelets, showing an up-regulation secondary to a deficit in serotonergic activity in major depression. however, their functional state has often been di

Physiological regulation of acute inflam

Physiological regulation of acute inflammation by A2A adenosine receptor

✍ Dmitriy E. Lukashev; Akio Ohta; Michail V. Sitkovsky 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB

Probabilistic Modeling of Platelet Aggre

Probabilistic Modeling of Platelet Aggregation: Effects of Activation Time and Receptor Occupancy

✍ ROBERT D. GUY; AARON L. FOGELSON 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 329 KB

A mathematical model is constructed to predict the probability that a collision between two activated platelets results in doublet formation mediated by fibrinogen cross-bridges. The model is used to explore the effect of time from activation, looking at both simultaneous and non-simultaneous activa