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Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin

✍ Scribed by Johannes Prox; Andrea Rittger; Paul Saftig

Book ID
113023013
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
565 KB
Volume
217
Category
Article
ISSN
0014-4819

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## Abstract One of the pathologic hallmarks of Alzheimer's disease is the excessive deposition of β‐amyloid peptides (Aβ) in senile plaques. Aβ is generated when β‐amyloid precursor protein (APP) is cleaved sequentially by β‐secretase, identified as β‐site APP‐cleaving enzyme 1 (BACE1), and γ‐secre