Physiological effects of nitro- and halo- substituted phenols in relation to extracellular and intracellular hydrogen ion concentration. II. Experiments with Arbacia eggs
✍ Scribed by Krahl, M. E. ;Clowes, G. H. A.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1938
- Tongue
- English
- Weight
- 920 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0095-9898
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✦ Synopsis
The data presented in the preceding paper of this series (Krahl and Clowes, '38) gave certain information regarding the modifications of physiological effect which may be induced by changing the nature and the arrangement of substituent groups in the phenol molecule. They did not afford any conclusive evidence regarding the respective roles of the substituted phenol molecules and anions in producing the various physiological effects observed.
Theoretical considerations presented in that paper indicated methods by which the physiological effects of the substituted phenols might be investigated and interpreted under the following conditions of pH : case I, constant extracellular pH and constant cytoplasmic pH ; case IT, varying extracellular pH and constant cytoplasmic pH ; case 111, constant extracellular pR and varying cytoplasmic pH ; case IV, varying extracellular pH and varying cytoplasmic pH. The purpose of this paper is, by utilizing the experimental possibilities enumerated under the above cases 11, 111 and IV, to ascertain, as f a r as is now possible, the respective roles played by the molecules and the anions of the substituted phenol in Case I was fully dealt with in the preceding paper.