Physiological disposition of fenoprofen in man II: Plasma and urine pharmacokinetics after oral and intravenous administration

✍ Scribed by Alan Rubin; Bruce E. Rodda; Patricia Warrick; Anthony S. Ridolfo; Charles M. Gruber Jr.

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 638 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600610514

✦ Synopsis

Two studies of dl-2-(3-phenoxyphenyl)propionic acid or fenoprofen are described. In these studies, the pharmacokinetic parameters of fenoprofen administered orally and intravenously were compared first and then urine and plasma kinetics were compared. The results indicate that: (u) fenoprofen is rapidly and efficiently absorbed from the GI tract; (b) fenoprofen is extensively metabolized, and it and its metabolites are rapidly eliminated from the body by the kidneys; and (c) good agreement exists between plasma and urinary kinetics. Key phrases 0 Fenoprofen-urinary and plasma kinetics compared after oral and intravenous administration, major urinary metabolites identified, man 0 dl-2-(3-PhenoxyphenyI)propionic acidurinary and plasma kinetics compared after oral and intravenous administration, major urinary metabolites identified, man 0 Urinary kinetics, fenoprofen--cornpared to plasma kinetics, major metabolites identified, man 0 Fenoprofen glucuronide-major urinary metabolite of fenoprofen, man 4'-Hydroxyfenoprofen glucuronide-major urinary metabolite of fenoprofen, man

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1 From the Indiana Reformatory.

2 All data are expressed in terms of the free acid (fenoprofen); corrections have been made for molecular weight differences.