Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates
β Scribed by Hagai Bergman; Ariela Feingold; Asaph Nini; Aeyal Raz; Hamutal Slovin; Moshe Abeles; Eilon Vaadia
- Book ID
- 117344263
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 231 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0166-2236
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The mechanism of parkinsonian tremor may involve a central oscillator, peripheral feedback to the central nervous system (CNS), or both. The thalamus or the globus pallidus is the most likely site for a central oscillator and would be predicted to generate thalamic tremor-related activity characteri
Dopamine (DA) neurons exist in two activity states; either spontaneously firing or quiescent and nonfiring. When faced with a behavioral demand, the quiescent DA neurons can be activated to facilitate normal motor output. Levodopa appears to increase DA output by activating these nonfiring neurons;
Degeneration of the nigrostriatal dopaminergic system is the characteristic neuropathological feature of Parkinson's disease and therapy is primarily based on a dopamine replacement strategy. Dopamine has long been recognized to be a key neuromodulator of basal ganglia function, essential for normal