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Physiologic changes in pregnancy and their effect on drug disposition

✍ Scribed by Marilynn C. Frederiksen

Book ID
114481429
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
332 KB
Volume
25
Category
Article
ISSN
0146-0005

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We investigated the effect of pregnancy on nitrofurantoin (NFT) disposition in wild-type and Bcrp1(-/-) mice. Pregnant and non-pregnant mice were administered NFT intravenously (5 mg/kg) or orally (10 mg/kg). Blood samples were collected at various times (5-60 min) after drug administration, plasma