Physicochemical Properties and Bioactivity of a Novel Class of Cellulosics: 6-Deoxy-6-amino Cellulose Sulfate

✍ Scribed by Taha Genco; Lidija Fras Zemljič; Matej Bračič; Karin Stana-Kleinschek; Thomas Heinze

• Book ID: 102942023
• Publisher: John Wiley and Sons
• Year: 2012
• Tongue: English
• Weight: 912 KB
• Volume: 213
• Category: Article
• ISSN: 1022-1352
• DOI: 10.1002/macp.201100571

✦ Synopsis

Abstract

The physicochemical behavior with emphasis on the charging behavior of 6‐deoxy‐6‐(2‐(bis(2‐aminoethyl)aminoethyl‐amino) cellulose sulfate (BAECS) with degree of substitution (DS) of 1.31 (sulfate moieties) and 0.71 (amino moieties) and of 6‐deoxy‐6‐(2‐aminoethyl) cellulose sulfate (AECS, DS~Sulf~ = 1.41, DS~DAE~ = 0.85, DS~Tosyl~ ≈0.09) is studied by using several types of titrations. The amounts of protonated amino groups determined by conductometric titration are 4.02 and 2.53 mmol g^−1^ for BAECS and AECS, respectively. The amino groups are fully deprotonated at pH ≥ 11, whereas the sulfate moieties determined by polyelectrolyte titration are fully dissociated at this pH value. Furthermore, studies on the antimicrobial and antithrombogenetic efficiencies of the samples are carried out.