Poly(ethylene oxide) (PEO) was used to prepare thin polymer films containing clotrimazole (CT) utilizing hot-melt extrusion (HME) technology. Films containing PEOs of two different molecular weights and the drug were investigated for solidstate characteristics, moisture-sorption, bioadhesivity, mech
✦ LIBER ✦
Physicochemical characterization of hot melt extruded bicalutamide–polyvinylpyrrolidone solid dispersions
✍ Scribed by Gavin P. Andrews; Osama A. AbuDiak; David S. Jones
- Book ID
- 102398608
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 254 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0022-3549
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The objective of the study was to characterize the physical and viscoelastic properties of binary mixtures of drug and selected polymers to assess their suitability for use in the hot-melt extrusion (HME) process as a means to improve solubility by manufacturing either solid dispersion or solid solu