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Physicochemical characterization of felodipine-kollidon VA64 amorphous solid dispersions prepared by hot-melt extrusion

โœ Scribed by Song, Yuejun; Wang, Lianyan; Yang, Ping; Wenslow, Robert M.; Tan, Bo; Zhang, Hailu; Deng, Zongwu


Book ID
120508527
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
724 KB
Volume
102
Category
Article
ISSN
0022-3549

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Nimodipine (NM) solid dispersions (SD) were prepared by hot-melt extrusion with polyvinylpyrrolidone/vinyl acetate copolymer (PVP-VA; Kollidon VA64) as the carrier, then the extrudate was stored at different temperatures (20ยฐC, 40ยฐC, 60ยฐC) after milling. Conventional differential scanning calorimetr