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Physicochemical behavior and cytotoxic effects of p(methacrylic acid–g-ethylene glycol) nanospheres for oral delivery of proteins

✍ Scribed by Madeline Torres-Lugo; Marcos Garcı́a; Rae Record; Nicholas A Peppas


Book ID
114161603
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
206 KB
Volume
80
Category
Article
ISSN
0168-3659

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## Abstract Effective oral delivery of proteins is impeded by steep pH gradients and proteolytic enzymes in the gastrointestinal tract, as well as low absorption of the proteins into the bloodstream because of their size, charge, or solubility. In this work, pH‐responsive complexation hydrogels of