Physicochemical and topological correlates of the enzymatic acetyltransfer reaction

✍ Scribed by S. C. Basak; D. P. Gieschen; D. K. Harriss; V. R. Magnuson

• Book ID: 102403471
• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 464 KB
• Volume: 72
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600720823

✦ Synopsis

The relative potencies of a series of substituted anilines as acetyl acceptors in the enzymatic N-acetylation reaction have been correlated using physicochemical substituent constants (r, c), molecular connectivity indices (lx, lxv), and newly formulated information-theoretic topological indices (IC, SIC). Results indicate a predominant role of the topological steric parameters in determining the rates of the Nacetyltransferase reaction.

Keyphrases 0 p-Nitroaniline-determination of the N-acetylation reaction, topological indices 0 Topological indices-information-theoretic, rate determination of the N-acetylation reaction, comparison with physicochemical constants and molecular connectivity indices, substituted anilines N-Acetylation reaction-of substituted anilines, enzymatic acetyltransferase, rate determination using information-theoretic topological indices