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Physicochemical analysis of the factors governing distribution of solutes between blood and brain

✍ Scribed by Harpreet S. Chadha; Michael H. Abraham; Robert C. Mitchell

Book ID
108476892
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
339 KB
Volume
4
Category
Article
ISSN
0960-894X

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The extent of brain delivery expressed as steady-state brain/blood distribution ratio (log BB) is the most frequently used parameter for characterizing central nervous system exposure of drugs and drug candidates. The aim of the current study was to propose a physicochemical QSAR model for log BB pr