Physicochemical analysis of (Pro-Pro-Gly)n with defined molecular weight–temperature dependence of molecular weight in aqueous solution

✍ Scribed by Yuji Kobayashi; Rume Sakai; Kinji Kakiuchi; Toshizo Isemura

• Publisher: Wiley (John Wiley & Sons)
• Year: 1970
• Tongue: English
• Weight: 521 KB
• Volume: 9
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/bip.1970.360090404

✦ Synopsis

Abstract

Sequenced polytripeptides, (Pro‐Pro‐Gly)~n~, (n = 10, 15, 20), with defined molecular weights were synthesized by the solid‐phase method. Conformational changes of these sample as a function of temperature were studied by measurements of optical rotation and sedimentation equilibrium. The temperature dependence of optical rotation was shown similar to thermal transition of collagen molecule. Each of these polymers existed as a timer at lower temperature. (Pro‐Pro‐Gly)~10~ existed as a monomer at higher temperature, and the others were expected to behave analogously.