Physical Virology: Virus Structure and Mechanics

✍ Scribed by Urs F. Greber

• Publisher: Springer International Publishing
• Year: 2019
• Tongue: English
• Leaves: 232
• Series: Advances in Experimental Medicine and Biology 1140
• Edition: 1st ed.
• Category: Library

✦ Synopsis

This book explores a new challenge in virology: to understand how physical properties of virus particles (virions) and viruses (infected cells) affect the course of an infection. Insights from the emerging field of physical virology will contribute to understanding of the physical nature of viruses and cells, and will open new ways for anti-viral interference.

Nine chapters and an editorial written by physicists, chemists, biologists and computational experts describe how virions serve as trail blazers in uncharted territory of cells. The authors outline how particles change in composition as they interact with host cells. Such virus dynamics are crucial for virus entry into cells and infection. It influences the modern concepts of virus-host interactions, viral lineages and evolution.

The volume gives numerous up-to-date examples of modern virology and provides a fascinating read for researchers, clinicians and students in the field of infectious diseases.

✦ Table of Contents

Front Matter ....Pages i-v
Editorial: Physical Virology and the Nature of Virus Infections (Urs F. Greber)....Pages 1-11
Single Virion Tracking Microscopy for the Study of Virus Entry Processes in Live Cells and Biomimetic Platforms (Lakshmi Nathan, Susan Daniel)....Pages 13-43
Structural Insights into Rotavirus Entry (Javier M. Rodríguez, Daniel Luque)....Pages 45-68
The HIV-1 Capsid: More than Just a Delivery Package (Leo C. James)....Pages 69-83
Membrane-Containing Icosahedral Bacteriophage PRD1: The Dawn of Viral Lineages (Hanna M. Oksanen, Nicola G. A. Abrescia)....Pages 85-109
Structure and Function of Negri Bodies (Jovan Nikolic, Cécile Lagaudrière-Gesbert, Nathalie Scrima, Danielle Blondel, Yves Gaudin)....Pages 111-127
Virus Maturation (Carmen San Martín)....Pages 129-158
Atomic Force Microscopy of Viruses (P. J. de Pablo, I. A. T. Schaap)....Pages 159-179
Alkalinization of Icosahedral Non-enveloped Viral Capsid Interior Through Proton Channeling (Maria Marta Branda, Diego M. A. Guérin)....Pages 181-199
Computational Virology: Molecular Simulations of Virus Dynamics and Interactions (Elizabeth E. Jefferys, Mark S. P. Sansom)....Pages 201-233

✦ Subjects

Biomedicine; Medical Microbiology; Virology; Infectious Diseases