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Physical status of the E2 human papilloma virus 16 viral gene in cervical preneoplastic and neoplastic lesions

✍ Scribed by S.A Tonon; M.A Picconi; P.D Bos; J.B Zinovich; J Galuppo; L.V Alonio; A.R Teyssie

Book ID: 117769422
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 150 KB
Volume: 21
Category: Article
ISSN: 1386-6532
DOI: 10.1016/s1386-6532(01)00155-x

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## Human-papillomavirus (HPV)-E2 protein is involved in gene-expression regulation and replication of HPV genome. Disruption of the E2 gene during viral integration has been proposed as a mechanism of tumoral progression, since the expression of E6/E7 viral oncogenes is allowed. However, retention