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Physical mapping of the retinoid X receptorBgene in mouse and human

✍ Scribed by Toshi Nagata; Elizabeth H. Weiss; Kuniya Abe; Kyoko Kitagawa; Asako Ando; Yukie Yara-Kikuti; Michael F. Seldin; Keiko Ozato; Hidetoshi Inoko; Makoto Taketo

Publisher
Springer-Verlag
Year
1995
Tongue
English
Weight
889 KB
Volume
41
Category
Article
ISSN
0093-7711

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✦ Synopsis

Retinoid X receptors (RXRs) are zinc fingercontaining nuclear transcription factors. They belong to the nuclear receptor superfamily that contains refinoid receptors, vitamin D receptors, thyroid hormone receptors, and steroid hormone receptors as well as the so-called orphan receptors. We previously mapped all three RXR genes on mouse chromosomes, using a panel of Mus spretus-Mus musculus interspecific backcross mice: Namely, the RXRAgene (Rxra) on Chr 2 near the centromere, the RXRB gene (Rxrb) on Chr 17 in the H2 region, and the RXRG gene (Rxrg) on distal Chr 1. Using cosmid clones that cover the major histocompatibility complex (MHC) region, we determined the precise physical map positions of the gene encoding mouse and human RXRB, respectively. The mouse gene (Rxrb) maps between H2-Ke4 and H2-Ke5:

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