Physical mapping of the 5 Mb D9S196-D9S180 interval harboring the basal cell nevus syndrome gene and localization of six genes in this region
✍ Scribed by Jingwu Xie; Anthony Quinn; Xiaoli Zhang; John Bare; Alana Rothman; Colin Collins; Steven Cutone; Marc Rutter; Mary Kay McCormick; Ervin Epstein Jr.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 149 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
The basal cell nevus syndrome (Gorlin syndrome) is characterized by multiple basal cell carcinomas and diverse developmental defects. The gene responsible for this syndrome has been mapped previously to a 2 cM interval between D9S196 and D9S180 at 9q22.3, and very recently mutations of a candidate gene in this region-the human homolog of the Drosophila patched gene-have been identified. We report here on physical mapping studies integrating a contig of yeast artificial chromosomes and bacterial artificial chromosomes with a long-range map spanning approximately 5 Mb between the recombinationdetermined flanking markers. Six genes have been mapped to this interval.