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Physical characterization of recombinant tissue plasminogen activator

โœ Scribed by Sarkis S. Margossian; Henry S. Slayter; Elzbieta Kaczmarek; Jan McDonagh


Book ID
113269119
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
971 KB
Volume
1163
Category
Article
ISSN
0167-4838

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The in vitro functional properties of recombinant tissue plasminogen activator (rt-PA), its biodistribution in mice, and its pharmacokinetics and clot localization properties in dogs have been investigated after labeling rt-PA with 111In. The rt-PA was coupled with the bicyclic anhydride of DTPA usi