Physical characterization of lansoprazole/PVP solid dispersion prepared by fluid-bed coating technique

✍ Scribed by Xingwang Zhang; Ningyun Sun; Baojian Wu; Yi Lu; Tianzheng Guan; Wei Wu

• Book ID: 104088759
• Publisher: Elsevier Science
• Year: 2008
• Tongue: English
• Weight: 474 KB
• Volume: 182
• Category: Article
• ISSN: 0032-5910
• DOI: 10.1016/j.powtec.2007.07.011

✦ Synopsis

The aim of this study was to characterize lansoprazole (LSP) /PVP solid dispersion prepared by a fluid-bed coating technique. In vitro dissolution test in pH 7.4 phosphate buffer indicated that the dissolution rate was dramatically enhanced even at an LSP/PVP ratio of 1/1.75 or with more PVP. DSC and powder X-ray diffractometry proved the absence of crystallinity in LSP/PVP solid dispersion at a ratio of 1/2 or with more PVP. However, at an LSP/PVP ratio of 1/1, the LSP melting and decomposition peaks could be observed by DSC indicating presence of LSP crystalline in LSP/PVP solid dispersion. The FTIR spectrometry indicated formation of hydrogen bond between LSP and PVP.