Physical aspects of wet granulations II: Factors involved in prolonged and excessive mixing
✍ Scribed by Michael A. Zoglio; H. E. Huber; Gerald Koehne; Ping Ling Chan; J. T. Carstensen
- Book ID
- 102404811
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- English
- Weight
- 418 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
Evidence is presented that excessive blending in a wet granulation process shifts the packing arrangement of the wet granule, causing it to become dense and nonporous. With prolonged kneading, a larger amount of the water-soluble excipients dissolves in the granulating fluid, and these two factors make the drying slower. This result, coupled with the previous finding that a certain time is required to attain an equilibrium size granule, explains why there exists an optimum kneading time for a wet granulation from a mechanical performance point of view.
Keyphrases 0 Granulations, wet-physical aspects, effect of prolonged and excessive mixing 0 Hardness, granule-effect of prolonged and excessive mixing Dissolution rate-wet granulations, effect of prolonged and excessive mixing '