Physical and chemical characterization insulin-loaded chitosan-TPP nanoparticles
✍ Scribed by J. R. Azevedo; R. H. Sizilio; M. B. Brito; A. M. B. Costa; M. R. Serafini; A. A. S. Araújo; M. R. V. Santos; A. A. M. Lira; R. S. Nunes
- Publisher
- Springer Netherlands
- Year
- 2011
- Tongue
- English
- Weight
- 368 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0022-5215
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## Abstract The objective of this work was to characterize a novel quaternary chitosan derivative [__O__‐(2‐hydroxyl) propyl‐3‐trimethyl ammonium chitosan chloride (__O__‐HTCC)] nanoparticle system. __O__‐HTCC nanoparticles were prepared with a simple and mild ionic gelation method upon the additio
## Abstract Various __N__‐acyl chitosans with propionyl‐, hexanoyl‐, nonanoyl‐, lauroyl‐, pentadecanoyl‐, and stearoyl‐groups were synthesized and self‐aggregated __N__‐acyl chitosan nanoparticles (CSNPs) were prepared by sonication. By the modification with __N__‐acyl groups, CSNPs increased their