Physical and biodegradation properties of A-B-A type block copolymer membranes consisting of poly(N-hydroxyalkyl-l-glutamine) as the a component and polybutadiene as the B component

✍ Scribed by Yoshinori Yoshida; Kenya Makino; Tetsuo Ito; yoshitaka Yamakawa; Toshio Hayashi

• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 547 KB
• Volume: 32
• Category: Article
• ISSN: 0014-3057
• DOI: 10.1016/0014-3057(96)00008-0

✦ Synopsis

A-B-A type block copolymer [GBG(A)] membranes consisting of poly(N-hydroxyalkyl-Lglutamine) ((SHAG) as the A component and polybutadiene (PB) as the B component were prepared by carrying out aminoalcoholysis reaction with 2-amino-l-ethanol or S-amino-1-pentanol (Pe) together with a crosslinking reaction with l&octamethylenediamine (OMDA) on membranes of the starting block copolymer ,membranes consisting of poly(y-benzyl L-glutamate) and PB. It was shown that the effective crosslink density was proportional to the molar % of OMDA in the reaction mixture. The relation between their bulk structure and membrane properties was investigated, such as the swelling ratio, q, in a pseudo-extracellular fluid (PECF), tensile properties, and enzymatic degradation behavior of the membranes in PECF. Tensile properties of the hydrophilic membranes were highly dependent on q in PECF, and on the hydrophobic portions in molecular chains, whose behavior was typical of an elastomer. Biodegradation of samples in vitro by papain indicated that the degradation was a bulk rather than a surface phenomenon, and that the rate of degradation was also highly dependent on q of membranes in PECF.